利用人工智能、单细胞多组学和基因编辑等交叉学科技术,解码增强子在发育和疾病(血液系统恶性肿瘤)的作用和机制。
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Our Team
Key Publications
D. Hong#, M. Shu#, J. Liu#, L. Liu, H. Cheng, M. Zhu, Y. Du, B. Xu, D. Hu, Z. Liu, Y. Zhao, J. Dai*, F. Lu*, J. Huang*. Divergent combinations of enhancers encode spatial gene expression. Nature Communications, 2025.
H. Lin#, X. Ye, W. Chen, D. Hong, L. Liu, F. Chen, N. Sun, K. Ye, J. Hong, Y. Zhang, F. Lu, L. Li, J. Huang*. Modular organization of enhancer network provides transcriptional robustness in mammalian development. Nucleic Acids Research, 2025.
D. Hong#, H. Lin#, L. Liu, M. Shu, J. Dai, F. Lu, M. Tong, J. Huang*. Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis. Briefings in Bioinformatics, 2023.
M. Shu#, D. Hong#, H. Lin, J. Zhang, Z. Luo, Y. Du, Z. Sun, M. Yin, Y. Yin, L. Liu, S. Bao, Z. Liu, F. Lu*, J. Huang*, J. Dai*. Single-cell chromatin accessibility identifies enhancer networks driving gene expression during spinal cord development. Developmental Cell, 2022.
J. Huang#, K. Li#, W. Cai, X. Liu, Y. Zhang, S. H. Orkin, J. Xu*, G.-C. Yuan*. Dissecting super-enhancer hierarchy based on chromatin interactions. Nature Communications, 2018;
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